Aspirin and sodium bicarbonate are not recommended to be taken at the same time, aspirin is an acidic drug, sodium bicarbonate is an alkaline drug, so it is not recommended to be taken at the same time, it will affect the efficacy. 1. Aspirin: is an acidic drug, suitable for inhibiting platelet aggregation, reduce myocardial infarction, temporary cerebral ischemia or stroke in patients with atherosclerosis, patients allergic to this product, patients with severe heart failure are prohibited from using it, the more common are nausea, vomiting, epigastric discomfort or pain and other gastrointestinal adverse reactions. 2. Sodium bicarbonate: It is a kind of alkaline drug used for the treatment of metabolic acidosis, alkalizing urine and so on. It can also be used as an acid-making drug to treat symptoms caused by excessive stomach acid. It is forbidden for those who are allergic to this product, and adverse reactions such as cardiac arrhythmia, muscle spasms, pain, and abnormal fatigue and weakness can occur when injected in large quantities. Aspirin and sodium bicarbonate are not recommended to be taken at the same time, and the medication must be implemented in accordance with medical advice.