Colds are caused by viral infections, accompanied by generalized fatigue are generally the clinical manifestations caused by viral infections, which can be relieved by general treatment and medication. 1. General treatment: The common cold caused by viral infection is generally a self-limiting disease. During the period of illness, patients should eat a light diet, drink plenty of water, and avoid eating spicy and irritating foods such as chili peppers and barbecue. Regular work and rest, ensure adequate sleep, enhance immunity, generally 7 to 10 days of general weakness can be relieved. 2. Medication: People with low immunity or influenza can take antiviral drugs such as oseltamivir. If the fever causes generalized weakness, you can target the use of acetaminophen, ibuprofen and other antipyretics. If there is a clear combination of bacterial infection, anti-infective treatment such as amoxicillin and levofloxacin is needed. Cold accompanied by generalized weakness, but also alert to the combination of tuberculosis and other diseases, the patient should seek medical attention as soon as possible, improve the relevant examination, such as blood routine, blood biochemistry, etc., a clear diagnosis. The above mentioned drugs should be taken under the guidance of a professional doctor.