Minimally invasive surgery for ankylosing spondylitis has better efficacy in relieving symptoms in the late stage of the disease. In the early and middle stages of ankylosing spondylitis, the disease mainly involves the lumbosacral joints or the low spine, and the symptoms are generally mild. At this time, conservative treatments are usually adopted, such as appropriate rest, physical therapy such as heat compresses and microwaves, oral non-steroidal anti-inflammatory drugs such as celecoxib or local injection of hormones and local anesthetics such as betamethasone and lidocaine. If ankylosing spondylitis is in the advanced or terminal stage, with obvious scoliosis, hunchback deformity, hip deformity, in the spinal segments or lumbosacral joints where the lesions are more serious, it can be treated by minimally invasive loosening of the local tissues to relieve the pain and other symptoms or orthopedic surgery of the spine. Ankylosing spondylitis is a lifelong disease, there is no authoritative literature showing that there is no cure, it is recommended to go to the hospital in a timely manner, follow the doctor’s instructions for regular treatment, so as not to delay the condition. The medication should be applied according to the doctor’s prescription.