Trimethoprim cream needs to be used externally on the face under doctor’s supervision, but usually the medication should not be used for more than 2 weeks. Trimethoprim cream is a compound preparation, the main ingredients are miconazole nitrate, tretinoin acetate, neomycin sulfate, etc., with anti-inflammatory, anti-allergic, anti-itch and other effects. Miconazole nitrate is an antifungal drug; Triamcinolone acetate is a glucocorticoid drug with anti-inflammatory, anti-allergic and antipruritic effects; Neomycin sulfate has a killing effect on Gram-positive and negative bacteria. Since tretinoin is a medium-strength hormone drug, it is usually not used for the treatment of the face, pubic area and other parts of the body. However, if the facial lesions are thick and a fungal or bacterial or mixed infection is considered, topical tretinoin cream can be used under the supervision of a doctor, usually for no more than 2 weeks. The drug can be used to treat eczema, contact dermatitis, seborrheic dermatitis, neurodermatitis, and ringworm. Adverse reactions such as burning skin sensation, itching and pins and needles sensation can occur after the use of the drug, and long-term use can cause localized skin atrophy, hyperpigmentation and hirsutism. It is recommended that the patient in the doctor’s guidance under the rational use of trimethoprim cream, not blindly self-medication, such as any discomfort during the use of medication, the need to stop the drug, cleaning, and go to the hospital, if necessary, follow the doctor’s advice to change to other drugs.