The causes of bilateral frontal-parietal sulcus widening include congenital brain dysplasia, physiologic brain atrophy, Alzheimer’s disease, etc., which need to be treated according to different causes. 1. Congenital dysplasia: it can be manifested as widening of the frontal-parietal sulcus. Patients with congenital dysplasia can be left untreated for the time being and followed up for observation if there is no abnormality in their intelligence, language expression level, motor level development and neurological reflexes. If there is persistent cerebral dysplasia, the patient needs to be treated with neurotrophic drugs, such as methylcobalamin and vitamin B12, as well as with rehabilitation training. 2. Physiological brain atrophy: with age, physiological widening of the frontal-parietal sulcus may occur, and there is no method to reverse physiological brain atrophy. 3. Alzheimer’s disease: Alzheimer’s disease also causes brain atrophy, which is manifested as widening of the frontal-parietal sulcus. Current treatments include medications such as acetylcholinesterase inhibitors (donepezil) and NMDA receptor antagonists (memantine), as well as cognitive training and music therapy. If bilateral widening of the frontal-parietal sulcus is detected, one should seek medical attention and follow the doctor’s instructions for treatment.