The side effects of chemotherapy for pancreatic cancer on the body include digestive tract reaction, skin adverse reaction, lung toxicity, cardiotoxicity and so on. 1. Digestive tract reaction: chemotherapeutic drugs such as paclitaxel will damage the mucous membrane cells of digestive tract and release 5-hydroxytryptamine, which will lead to nausea, vomiting, diarrhea and other symptoms. 2. Skin adverse reactions: fluorouracil, capecitabine and other chemotherapeutic drugs will cause high expression of thymidine phosphorylase in the skin, causing toxic accumulation, which will lead to the appearance of rashes, skin reactions on hands and feet, skin dryness, itching and other symptoms. 3. Lung toxicity: some chemotherapeutic drugs can damage lung tissue cells and even lead to pulmonary fibrosis, resulting in symptoms such as coughing and shortness of breath. 4. Cardiotoxicity: anthracycline, paclitaxel and other chemotherapeutic drugs will lead to swelling and degeneration of cardiomyocytes, and myocardial fibers will be dissolved and broken, resulting in symptoms such as congestive heart failure, heart rupture, and dyspnea. If symptoms related to chemotherapy occur, it is recommended to inform the doctor, and under the doctor’s guidance to carry out the next examination and formulate a personalized treatment plan. Please strictly follow the doctor’s instructions for medication, and do not use medication on your own.