There are two main types of reasons for waking up in the second half of the night: First, occasionally waking up in the second half of the night, because the patient sleeps too much during the daytime, resulting in waking up very early in the second half of the night, and it is difficult to fall asleep after waking up. This type does not need medication, through the adjustment of work and rest habits, appropriate physical exercise, to correct the sleep rhythm abnormalities. Second, somatic diseases lead to wake up in the second half of the night, it is recommended that patients go to the regular hospital to improve the blood glucose, blood pressure, blood lipids, as well as nocturnal polysomnography, cranial CT or magnetic resonance and other tests, to clarify the specific causes of the disease. If there are patients with abnormal blood glucose, blood lipids, blood pressure, it is recommended to strictly control blood pressure, blood glucose, blood lipids.