Helicobacter pylori has a certain effect on duodenal cancer, but it is mostly unrelated to colon cancer and rectal cancer. H. pylori infection is prone to gastric ulcers and duodenal ball ulcers, followed by abdominal discomfort, nausea, vomiting, heartburn and other discomforts, and duodenal cancer is possible if symptomatic treatment is not given in time. Helicobacter pylori does not normally parasitize the colon and rectum, and therefore does not pose a threat to the colon and rectum. It is important to note that patients with duodenal cancer can minimize the adverse effects of the disease by early intervention through “early detection, diagnosis and treatment”. Seek immediate medical attention when discomfort occurs, and intervene as soon as possible under the guidance of a medical professional.