Penile itching is mostly seen in fungal infection, bacterial infection, penile eczema, etc., generally need to use antifungal, antibiotic, anti-allergy, hormone drugs, etc.. 1. Fungal infection: may be fungal infection caused by glans, can be used locally antibacterial cream, such as miconazole cream, ketoconazole cream, if the fungal infection is serious, with oral antifungal drugs, such as itraconazole, terbinafine. 2. Bacterial infection: mainly bacterial infection caused by inflammation, can be applied locally erythromycin ointment, mupirocin ointment, serious inflammation with oral roxithromycin, azithromycin. 3. Penile eczema: a chronic allergic skin disease, can be applied locally hormonal ointment, such as dinexed cream, dexamethasone cream, and with oral cetirizine hydrochloride, loratadine, and so on. All of the above medication should be in accordance with the doctor’s instructions, patients should not self-medication, so as not to delay the condition.