Intrahepatic cholangiocellular carcinoma has a poor prognosis and the exact survival period is currently inconclusive. Some studies claim that its overall 5-year survival rate is generally around 20%, and it is difficult to achieve a cure. Intrahepatic cholangiocellular carcinoma is a special type of hepatocellular carcinoma, which refers to malignant tumors originated from epithelial cells of the secondary bile ducts and their branches in the liver, and adenocarcinoma is the main type. Early stage intrahepatic cholangiocellular carcinoma patients often have no obvious clinical symptoms, but the disease progresses rapidly, and most of them are already in middle or late stage when diagnosed. The prognosis of intrahepatic cholangiocarcinoma is related to age, disease stage and treatment effect. 1. According to foreign studies, if patient’s condition and disease stage are not taken into consideration, the overall 1-year survival rate of intrahepatic cholangiocarcinoma is 51.4%, the 3-year survival rate is 22.14%, and the 5-year survival rate is only 13.79%; 2. Early stage patients can usually be resected by surgery, but still maintain a high recurrence rate, and chemotherapy and other adjuvant treatments are recommended after surgery. Some studies claim that their 1-year survival rate is about 60%, 3-year survival rate is about 35%, and 5-year survival rate is about 25%. In addition, this group can receive liver transplantation, and its 5-year survival rate is about 30-35%. 3. If cholangiocarcinoma patients who cannot be treated surgically do not receive systemic treatment such as chemotherapy, their 1-year survival rate is less than 30%. 4. In addition, its prognosis is also related to the degree of differentiation, lymph nodes and distant metastasis. In conclusion, the prognosis of intrahepatic cholangiocarcinoma is poor, and early diagnosis and early treatment are the keys to improve the prognosis. It is recommended to go to regular hospitals for consultation and treatment and follow the doctor’s instructions to avoid delaying the condition.