Pill of Radix Rehmanniae Pill and Four Spirits Pill are two different types of proprietary Chinese medicines, with different drug composition, efficacy and main treatments. 1. Composition: Radix Rehmanniae Pill is composed of Radix Rehmanniae Praeparata, Radix et Rhizoma Glycyrrhizae, Radix et Rhizoma Ginseng, Rhizoma Atractylodis Macrocephalae and Radix et Rhizoma Glycyrrhizae. 2. Efficacy: Radix Rehmanniae Pill is a medicine for warming the middle Jiao and dispersing cold (dispersing cold by warming the spleen and stomach), which mainly has the efficacy of warming the middle Jiao and strengthening the spleen; Si Shen Pill is a medicine for warming the kidney and yang, which mainly has the efficacy of warming the kidney and dispersing cold (warming the kidneys and dispersing cold), and astringing the intestines to stop diarrhea (alleviating diarrhea by enhancing the intestinal astringency function). 3. Indications: Radix Rehmanniae Pill is mainly used for the treatment of cold pain in the epigastrium (cold pain in the stomach and abdomen), vomiting and diarrhea, and lack of warmth in the hands and feet due to deficiency of kidney yang (lack of yang qi in the kidneys); Sisi Pill is mainly used for the treatment of diarrhea due to deficiency of kidney yang (lack of yang qi in the kidneys), which includes intestinal tinnitus and abdominal distension, loose stools in the fifth day of the week, prolonged diarrhea, and yellowish face with cold limbs, etc. It is contraindicated in treating diarrhea. The medication is contraindicated in people who are allergic to the product, allergic people should be cautious, should not be taken by patients with colds and fever, pregnant women should be cautious, patients with severe chronic diseases, children, lactating women should be taken under the guidance of a physician; the contraindications and precautions of Sishen Pills are still not clear. Specific medication should be under the guidance of a physician, do not take medication without authorization, so as not to cause adverse reactions.