Not all diffuse hepatic injury must undergo liver transplantation. For diffuse hepatic injury caused by cirrhosis, anti-cirrhosis treatment can be carried out, and liver transplantation is feasible if diffuse hepatic injury results in irreversible liver failure. At present, the clinical treatment for diffuse liver injury is symptomatic treatment. If the injury is caused by alcohol consumption, it is necessary to quit drinking in time, and if the injury is caused by viral hepatitis, it is necessary to carry out antiviral treatment under the guidance of doctors. However, diffuse liver injury may progress and develop into cirrhosis, liver cancer, etc. If liver function continues to decline and irreversible liver failure occurs, liver transplantation is recommended. Diffuse liver injury requires timely improvement of relevant examinations, active cooperation with doctors to clarify the diagnosis and standardize the treatment to avoid deterioration of the situation.