Breathing chest pain while sleeping may be caused by thoracic and pulmonary diseases, cardiovascular diseases, chest wall diseases and spinal disorders, etc., and you should consult a doctor in time to find out the cause. 1. Chest and lung diseases: such as pleurisy, pneumonia, lung tumor, mediastinal tumor and so on. Chest pain is usually related to breathing or coughing, which will be aggravated during deep breathing or coughing, and in serious cases, it will be accompanied by dyspnea. 2. Cardiovascular diseases: All kinds of cardiovascular diseases may lead to chest pain at night, mainly angina pectoris, myocardial infarction, pericarditis and so on. This type of chest pain is mostly manifested in the precordial area and post-sternal pressure pain or stuffy pain. 3. Chest wall diseases: such as rib fracture, costochondritis, intercostal neuralgia and so on. These chest wall diseases cause chest pain not only at night when sleeping, but also during the day. 4. Spinal diseases: human spinal nerves and autonomic nerves will be sent to the chest wall, diaphragm, heart and other parts of the body. If the spinal intervertebral slight misalignment is caused by trauma, strain or wind-cold, or inflammatory changes, it will stimulate the relevant spinal nerves or autonomic nerves, which will cause chest pain. However, other factors can not be ruled out as well. It is recommended to consult a doctor in time to give targeted treatment after the cause is clarified by the doctor.