For Hashimoto’s hypothyroidism and melasma, the onset and progression of the two diseases are not obviously related, and corresponding treatments can be taken separately, with the administration of levothyroxine for the treatment of hypothyroidism, topical medication for the treatment of melasma, attention to diet, and reduction of light exposure. 1. Hashimoto’s hypothyroidism: Generally, levothyroxine is used for replacement therapy, and the goal of the treatment is to maintain the thyroid hormone to the normal range. 2. Melasma: It is necessary to minimize the exposure to sunlight, and it can be treated with topical medication (such as hydroquinone cream), medicated masks, laser treatment, etc. Pay attention to avoiding sunlight and sunshine, and consume more vitamin-rich fresh fruits and vegetables. The above medicines and treatments need to be carried out under the guidance of doctors, and you should not buy and use medicines by yourself to avoid delaying the condition.