Smallpox vaccine is categorized into two types: strong live vaccine and live attenuated vaccine, and the number of times and methods of vaccination differ between the two types of vaccine. 1. Strongly virulent live vaccine: vaccination once. Vaccination method preferred forked needle multiple chopping technique, that is, in the inoculation site 5mm diameter range, according to the number of chopping to the manual with a forked needle quickly, multiple chopping skin, usually 10 ~ 20 seconds after the injection site appears blood spots. 2. Live attenuated vaccine: This vaccine usually needs to be vaccinated twice, usually every 4 weeks. Generally, the skin scratch method can be used, i.e., a drop of vaccine is placed at the vaccination site and a 3~5mm mark is made through the vaccine with a sterilized needle, and small unconnected blood spots will appear on the epidermis. Smallpox vaccination needs to follow the doctor’s instructions strictly. At the same time, you need to do a good job of personal protection after vaccination to avoid the occurrence of infection at the injection site.