Adults with patent foramen ovale without symptoms and cardiac damage can be left untreated; adults with patent foramen ovale without symptoms, such as paradoxical embolism, require prompt pharmacologic or surgical treatment. Ovarian aperture is relatively common in the population without discomfort such as dyspnea or decreased activity tolerance, and without organic cardiac pathology, and does not require special treatment. For those with a higher risk of stroke or hemorrhage, medication is recommended. Antiplatelet therapy with aspirin and clopidogrel can be prescribed. For the recurrence of stroke, deep vein thrombosis, and hypercoagulable state during antiplatelet therapy, anticoagulant therapy with warfarin may be used instead. For cases such as cerebral hemorrhage combined with patent foramen ovale, moderate or large amount of right-to-left shunt of blood, intractable or chronic migraine combined with patent foramen ovale, combined with venous thrombosis or varicose veins of the lower limbs, upright hypoxemia with patent foramen ovale, etc., surgical or interventional occlusion therapy is required. It is recommended to visit a hospital to determine whether treatment is needed for an unclosed foramen ovale. Specific medication should be prescribed by the doctor.