Retinoic acid cream does not directly reduce the size of pores, but it can regulate the process of epithelial keratinization of sebaceous glands of hair follicles and remove keratin plugs, and ultimately achieve the purpose of improving the enlarged pores. The main ingredient of retinoic acid cream is all-trans retinoic acid, which has the effect of inducing epidermal cell proliferation and dissolving keratin, through regulating the abnormal process of epithelial keratinization of the sebaceous glands of the follicles and removing the keratin plugs, so as to improve the enlarged pores and eliminate the purpose of pimples. Adverse effects such as burning sensation, erythema and flaking of the skin may occur during treatment, but generally no discontinuation of the medication is necessary. If the symptoms are severe and continue to worsen, the medication may be suspended or intermittently used under the supervision of a doctor. It is contraindicated in pregnant and lactating women. In order to ensure the safety of the medication, it is important to use the medication in strict accordance with the doctor’s instructions.