Thyroid parenchymal echogenicity hyperechoic thickening uneven distribution is a manifestation of ultrasound examination, considering the Hashimoto’s thyroiditis, hyperthyroidism, thyroid cancer and other diseases caused by the need for targeted treatment under the guidance of the doctor, such as drug therapy, surgical treatment, and so on. 1. Hashimoto’s thyroiditis: patients with hypothyroidism can take levothyroxine sodium tablets as prescribed by the doctor, and those who do not have obvious clinical manifestations and have normal thyroid function can have regular checkups. 2. Hyperthyroidism: need to take antithyroid drugs, such as methimazole, propoxythiopyrimidine, etc.; can also consider radioactive iodine treatment, surgery, etc.. 3. Thyroid cancer: the main treatment is surgery, which includes half thyroidectomy, total thyroidectomy, etc. After surgery, levothyroxine sodium tablets can be used to inhibit the secretion of thyroid stimulating hormone. In case of hyperechoic and thickened thyroid parenchyma with uneven distribution, it is recommended to go to the hospital and ask the doctor to make a judgment and give a treatment plan.