Tuberculosis only take rifampicin generally have a certain effect, but may not reach the cure effect, alone may quickly develop drug resistance, the combination of drugs is tuberculosis patients need to follow the principle of treatment. TB is an infectious disease caused by Mycobacterium tuberculosis infection, which can damage the lungs. TB patients should follow the principles of early, combined, moderate, regular, and complete treatment in order to get good results. Rifampicin is one of the first line of treatment for TB. Rifampicin alone may have some effect, but it may also produce drug resistance in a short period of time, which may not lead to a cure. The clinical principle of treating tuberculosis is to use a combination of drugs in order to cross-kill the tuberculosis bacilli and minimize the incidence of natural drug-resistant bacteria. When using rifampicin, it should be noted that the use of this drug may cause hepatotoxicity, gastrointestinal reactions and other side effects. Rifampicin also needs to be contraindicated in women in the first trimester of pregnancy, those with severe liver insufficiency, those with bile duct obstruction, and those who are allergic to the ingredients contained in rifampicin. Once an individual is diagnosed with tuberculosis, he or she should consult a hospital in a timely manner, follow the doctor’s instructions to choose the right medication for him or her, and try to do a good job of isolating himself or herself during the treatment period.