Frozen shoulder is a chronic, specific inflammation of the shoulder capsule and its surrounding ligaments, tendons and bursae that is characterized by a gradual onset of pain in the shoulder, especially at night, and a progressive worsening of the shoulder joint function. The age of onset of the disease is around 50 years old, and the incidence is slightly higher in women than in men. If not treated effectively, it may seriously affect the functional activities of the shoulder joint. It is also referred to as 50 shoulder. Currently, the main treatment for frozen shoulder is conservative. Oral anti-inflammatory and analgesic drugs, local closure of painful spots, massage and tui-na, and other comprehensive therapies. At the same time, functional exercises are performed, including active and passive abduction, rotation, extension and flexion, and circular rotation exercises. When the shoulder pain is significantly reduced but the joint is still stiff, the joint can be released by manipulation under general anesthesia to restore the range of motion of the joint. Our department is now using a combination of ozone therapy, which has greatly increased the efficiency. Ozone is widely used in clinical practice because of its strong oxidizing power and biological effects such as bactericidal, antiviral, anti-inflammatory, analgesic and immunomodulatory effects. Ozone injection is a safe, effective, economical and analgesic treatment with few adverse effects for the treatment of many chronic painful diseases. Ozone can stimulate the overexpression of oxidative enzymes, neutralize the overproduction of reactive oxidative products in the inflammatory response, antagonize the release of immune factors in the inflammatory response, dilate blood vessels, improve reflux, and reduce edema around nerve roots. It can also act directly on nerve end-piks and stimulate the release of enkephalins and other substances from inhibitory interneurons, thus achieving analgesic effects.