1. Glycoantigen 72-4 (CA72-4), one of the glycoantigens, also known as glycoconjugate antigen 72-4 (CA72-4) and cancer antigen 72-4, is a high molecular weight blood group antigen that is a broad-spectrum tumor marker found mainly in the stomach, ovaries, pancreas, breast, large intestine, and lung. It is a high molecular weight (relative molecular weight >106kDa) mucin with a disaccharide antigenic determinant cluster; a glycoconjugate antigen recognized by two monoclonal antibodies, cc49 and B72.3. cc49 is a TAG-72 antigen produced from cultured colon cancer cells. The monoclonal antibody is a monoclonal antibody to the TAG-72 antigen produced from colon cancer cells, and B72.3 is a monoclonal antibody to the liver metastases from breast cancer cells.
2. As a good new tumor marker, serum CA72-4 is an indispensable and useful indicator in the diagnosis, prognosis, follow-up, monitoring of treatment and recurrence of gastrointestinal cancer, ovarian cancer, lung cancer, breast cancer, mucinous cystic adenocarcinoma of the ovary, and non-small cell lung cancer, and the detection of the glycoantigen CA72-4 is of great importance in clinical diagnosis.