Glucocorticoids are now widely used in connective tissue diseases, and osteoporosis is one of the most serious side effects if hormone drugs are taken for a long time. Even taking physiological doses of glucocorticoids may cause bone loss, which is most common in drug-induced osteoporosis, so patients are advised to take calcium tablets or other calcium supplements at the same time to prevent osteoporosis. Severe osteoporosis may result in back and leg pain, peripheral aches and pains, restricted movement, and even difficulty turning over, sitting up, and walking. More serious osteoporosis is the occurrence of fractures, such as compression fractures of the thoracic and lumbar vertebrae, and non-traumatic or minor traumatic fragility fractures. Moreover, osteoporosis can cause many hazards, such as pain that can reduce the quality of life of the patient. Fractures may lead to disability, limiting the patient’s mobility and inability to care for himself, as well as increasing the risk of lung infections and decubitus ulcers can affect the patient’s quality of life.