Elevated pepsinogen 2 is only a reference indicator that suggests atrophic gastritis may exist in the stomach, and is not a criterion for the presence of gastric cancer. Pepsinogen 2 is secreted by gastric fundus glandular cells and mucus neck cells, and its normal range is 1~15ug/L. Higher pepsinogen 2 suggests that there is damage to gastric mucosa, which is mostly seen in gastric fundus glandular atrophy, metaplasia, Helicobacter pylori infection, and peptic ulcer, etc. Pepsinogen 2 is classified into pepsin 1 and pepsin 2. Pepsinogen is divided into pepsinogen 1 and pepsinogen 2, when there is a decrease in pepsinogen 1 and an increase in pepsinogen 2, it suggests that there is a higher risk of tumors in the stomach. Therefore, when the elevation of pepsinogen 2 is detected by blood sampling in physical examination, it is recommended to do gastroscopy screening, and only when atrophic gastritis is seen in the stomach under gastroscopy or there is suspected gastric mucosal lesion, can the pathology be taken to determine whether gastric cancer occurs or not. It is recommended to go to regular hospital for clear diagnosis and standardized treatment.