Systemic pruritus medication can choose local topical drugs and systemic drugs, need to clarify the presence of diabetes mellitus and other systemic diseases and active treatment. 1. Local topical medication: you can choose antipruritic agents such as glycerite lotion, ethanol preparation containing menthol, camphor or cream, surface anesthetics such as lidocaine cream; dry skin can be used as emollients, short-term topical glucocorticosteroids can alleviate the symptoms, because of its adverse effects, can not be used for a long period of time. 2. Systemic medication: generally used antihistamines, such as promethazine, loratadine, etc.; tricyclic antidepressants, such as doxepin, amitriptyline; hormonal drugs, such as dexamethasone, prednisolone and so on. Drugs need to be used under the guidance of a doctor. For generalized itching symptoms are more serious or can not be relieved, may also be combined with diabetes and other systemic diseases, it is recommended to go to the hospital for specialist diagnosis and treatment, so as not to delay the condition. Usually patients should pay attention to maintain a relaxed mood, eat a light diet; avoid rubbing and hot water when bathing.