Currently there is no gout medication that does not harm the kidneys at all. Drugs such as febuxostat and allopurinol are relatively less damaging to the kidneys, but they are not completely free of kidney damage. Commonly used drugs for gout treatment are non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, colchicine, glucocorticosteroids such as prednisone, and uric acid-lowering drugs such as febuxostat, of which glucocorticosteroids can be used in the case where there are contraindications to NSAIDs and colchicine, or where the application of these two medications is ineffective in treating the problem, and they can alleviate the symptoms and cause less damage to the kidneys in relative terms. In addition to febuxostat, allopurinol are two uric acid-lowering drugs, less damage to the kidneys, can be used for mild to moderate renal impairment of gout patients treatment. Although Febuxostat, allopurinol and other drugs relatively less damage to the kidneys, but because most of the drugs need to be metabolized by the liver and kidneys, so it is not completely free of damage to the kidneys. Drugs should be used under the guidance of a physician, and gout patients are advised to go to the rheumatology and immunology departments of regular hospitals for detailed consultation on related matters, and to avoid taking medication on their own.