This virus of coxsackievirus group A type 16 can cause hand, foot, and mouth disease, as well as herpes pharyngitis, or an insidious infection. It causes hand, foot and mouth disease as well as herpes pharyngitis, which is not very serious. The more serious cases of HFMD, which are examples of severe disease, are caused by enterovirus 71, because this virus has a more pronounced neurophilic nature, whereas coxsackievirus group A type 16, which is relatively less likely to cause severe disease. So if on a child who has HFMD, the test reveals a positive coxsackievirus group A type 16 and a negative enterovirus 71, there is no particular concern at that point. However, each child is different, such as coxsackievirus group A type 16, and children with HFMD should also be judged by symptoms, clinical manifestations, and relevant ancillary tests to determine the severity, and it is not possible to assume that because it is this viral infection, it will not develop into a serious disease.