Melatonin is an amine hormone (highly potent biologically active substance) secreted by the pineal gland. Melatonin receptor agonists are a class of drugs that work by agonizing melatonin receptors. Melatonin is a tryptophan-based amine hormone produced by the pineal gland in the body. Melatonin production is higher before puberty and decreases with age after puberty. The secretion of melatonin shows a clear circadian rhythm, the secretion of melatonin is significantly higher at night than during the day, and reaches a peak at 2:00 a.m. Melatonin has a sedative, hypnotic, analgesic, antidepressant, and adjusting the biorhythms (to promote sleep) and other effects. Melatonin receptor agonists are a class of drugs that play a role by agonizing melatonin receptors, commonly used in the treatment of insomnia, antidepressant, commonly used drugs, including: Agomelatine, etc., during the period of time when the drug is prohibited from drinking alcohol and smoking, drinking coffee, strong tea and other excitatory beverages, the taking of such drugs must comply with the doctor’s instructions, to avoid the occurrence of adverse reactions, affecting the effectiveness of the treatment. It is recommended that patients should consult a doctor in time if they feel unwell, and should not take medication blindly on their own to avoid delaying or aggravating their condition.