Patients with leg pain and leg numbness take the following types of drugs effectively: First, non-steroidal anti-inflammatory, analgesic and painkilling drugs: such as celecoxib, loxoprofen sodium, ankamycin, pautazone, ibuprofen, etc. Such drugs can eliminate inflammation and relieve leg pain, especially inflammation of the nerves. Second, drugs that nourish the nerves: such as vitamin B1, vitamin B6, vitamin B12, can repair the nerves, restore nerve function, make the nerve inflammation and edema subside, and relieve the symptoms of leg numbness and leg pain. Through the comprehensive treatment of several drugs above, the symptoms of leg numbness and leg pain can be rapidly relieved. Patients should also protect the lumbar spine and sciatic nerve in general to avoid inflammation and edema of the nerve, and should strengthen the exercise of the lumbar back muscle and avoid sedentary.