Anal skin whitening and itching may be associated with anal fissure, anal fistula, perianal eczema, anal leukoplakia, vitiligo and other diseases, need to be further differential diagnosis by the doctor. 1. Anal fissure: If the fissure is not healed for a long time, ulceration occurs, which can cause localized white anal skin with itching symptoms. 2. Anal fistula: due to the fistula mouth often overflow liquid, can stimulate the anal skin caused by itching, there will be external mouth around the anal skin whitening, hyperplasia phenomenon. 3. Perianal eczema: local skin pimples, usually intense itching, often scratching the skin can cause erosion, can also be manifested as whitening. 4. anal leukoplakia: anal skin whitening, color loss, point-like changes, may be perianal sclerosing moss, vitiligo, etc., accompanied by perianal itching, skin atrophy and other symptoms. 5. Vitiligo: there are varying degrees of dehiscence around the anus, there is a layer of diffusion ring around the white patches, ultraviolet irradiation will be manifested as erythema, blisters, itching, etc., the lesions are affected by emotions, immunity and so on. The anal skin white and itchy people, it is recommended to go to the hospital in time, clear cause, follow the doctor’s instructions in the guidance of a professional doctor for standardized treatment, so as not to delay the condition.