Leakage of heart beat is mainly considered as premature beats and atrioventricular block, and the drugs for treatment are beta-blockers propranolol, propafenone, amiodarone, verapamil, atropine, salbutamol, isoprenaline, etc. 1. Premature beats: premature beats can appear as missed beats, which is the most common arrhythmia. Premature beats can be categorized into atrial, ventricular and atrioventricular junction premature beats, of which ventricular premature beats are the most common. Atrioventricular junctional premature beats are mainly treated with etiologic therapy and removal of triggers, and generally do not need antiarrhythmic drugs. For atrial and ventricular premature beats without organic heart disease with obvious symptoms affecting normal life, drugs can be given appropriately, and β-blocker propranolol, propafenone, verapamil and other drugs can be used; for atrial and ventricular premature beats with chronic organic heart disease and obvious symptoms, amiodarone treatment is advocated at present. For atrial and ventricular premature beats in chronic organic heart disease with obvious symptoms, amiodarone is mostly recommended. 2. Atrioventricular block: Atrioventricular block can appear the sense of heart beat shedding, can be divided into one degree, two degrees, three degrees of atrioventricular block, one degree of atrioventricular block generally do not need drug treatment, two degrees and three degrees of atrioventricular block patients with obvious symptoms, can be given to improve the ventricular rate of atropine, salbutamol, isoproterenol, and other drugs. When patients have obvious symptoms, they should go to the hospital in time.