Hiccups are usually associated with diaphragmatic spasm, gastritis, esophagitis, etc., and can be treated with medication such as drinking hot water, increasing gastric motility, proton pump inhibitors, etc. depending on the cause. 1. Drinking hot water: hiccups after staying up all night may be caused by drinking water, eating, getting cold, etc., which causes spasm and contraction of the digestive diaphragm, and hiccups can be relieved by drinking hot water. 2. Increase gastric power drugs: gastritis can also lead to hiccups when patients stay up late, usually recommended to use domperidone and other drugs to increase gastric power for treatment. 3. Proton pump inhibitor drugs: a stay up late hiccups may also be caused by esophagitis, usually recommended the use of omeprazole, lansoprazole, rabeprazole and other proton pump inhibitor drugs for treatment. The above drugs need to be used under the guidance of a doctor, if the hiccups are not relieved, or accompanied by other symptoms, you should go to the hospital in a timely manner, to clarify the cause of the targeted treatment.