Chronic osteomyelitis is also known as osteomalacia in Chinese medicine. Generally used in the treatment of chronic osteomyelitis of Chinese medicine is divided into internal medicine and external medicine, such as five flavors disinfectant drink, ten complete tonic soup, Yu Lu cream and so on. 1. Internal medicine: during the acute attack of inflammation of this disease, there are local swelling and pain, pus flowing from the sinus opening, accompanied by fever, general discomfort, local pressure and percussion pain, it is suitable to take Wuwei disinfectant drink or Tori Jin Yin Di Ding San. In the non-acute stage, the symptoms subside, the affected part has hidden pain, and the sinus tract is not healed for a long time, so it is better to take Shen Gong Nei Tuo San; and for those who have deficiency in qi and blood, it is better to take Shiquan Dazhuang Tang. 2. External medicine: apply Jin Huang San and Yu Lu Cream externally during the acute attack of inflammation of this disease; rinse the ulcerated or cut sores with Bing Huang Liquid or San Huang Liquid. In the non-acute period when the local skin is free of sores and sinus tracts, external application of Baidu Gangrene Dispersion; if the sinus tracts don’t heal for a long time, use Sanqi Danxian line to insert into the sores, and external application of Shengmiao Yuhong Cream. Chronic osteomyelitis of traditional Chinese medicine treatment, need to be under the guidance of the doctor to identify the evidence of the use of drugs, can not be used on their own, in order to avoid improper operation of the drug or aggravate the condition.