The lack of appetite in patients with nephrotic syndrome may be caused by gastrointestinal dysfunction and slowing down of gastrointestinal peristalsis. Patients with nephrotic syndrome will have elevated creatinine and water retention, which will cause gastrointestinal dysfunction and will interfere with gastrointestinal peristalsis, and patients may have clinical manifestations such as loss of appetite, nausea, vomiting, abdominal distension and diarrhea. In addition, some patients with nephrotic syndrome will also have pleural effusion and abdominal effusion, when the abdominal cavity contains a large amount of fluid, it will limit the peristalsis of the gastrointestinal tract, and the patients will also have no appetite, indigestion, and even abdominal distension, diarrhea and other clinical manifestations. Some patients with nephrotic syndrome have a mild condition, which may not affect the digestive system. When patients with nephrotic syndrome have reduced appetite, they should go through relevant examinations under the guidance of professional doctors to clarify the development of the disease and follow the doctor’s instructions to choose the appropriate treatment plan.