High anti-streptococcal hemolysin O may be related to rheumatic fever, acute glomerulonephritis, nephrotic syndrome and other diseases. 1. Rheumatic fever: Rheumatic fever can lead to high antistreptococcal hemolysin O, which is manifested by redness, swelling and pain in large joints, as well as symptoms of panic and chest tightness. 2. Acute glomerulonephritis: when acute glomerulonephritis occurs, the level of anti-streptococcal hemolysin O can be high, and at the same time, there are elevated blood pressure, edema, proteinuria and so on. 3. Nephrotic syndrome: patients with nephrotic syndrome show increased levels of anti-streptococcal hemolysin O, but also have large amounts of proteinuria, hypoproteinemia, hyperlipidemia and so on. It is recommended that patients with nephrotic syndrome should consult the rheumatology and immunology department of regular hospitals to identify the cause of the disease and follow the doctor’s instructions for standardized treatment.