Roughness of the mucosa under the cardia is usually caused by chronic gastritis, gastric ulcer, gastric cancer and other diseases, which need to be clearly diagnosed and choose the appropriate way of treatment, including general treatment, medication, surgery and so on. 1. Chronic gastritis: If chronic gastritis causes roughness of mucous membrane under cardia, patients should adjust their diet and living habits, and if Helicobacter pylori infection exists, take omeprazole, amoxicillin, metronidazole, bismuth pectin and other medicines according to doctor’s instruction. 2. Gastric ulcer: gastric ulcer can also lead to mucosal roughness below the cardia, patients can take acid inhibiting drugs to reduce the acidity of the stomach as prescribed by the doctor, such as omeprazole, rabeprazole and so on. It is also necessary to combine with gastric mucosa protection agents, such as magnesium aluminum carbonate, aluminum thioglycollate and so on. 3. Gastric cancer: roughness of mucous membrane under cardia may also be caused by gastric cancer. For patients with gastric cancer, surgical resection should be the mainstay in the early stage, and combined with radiotherapy and chemotherapy after surgery to improve the treatment effect. For those who are found to have rough mucous membrane under cardia, they should consult doctor for examination and choose appropriate way of treatment.