Trimethoprim is mainly used for the treatment of gastrointestinal motility disorders and irritable bowel syndrome, and it has a wider range of co-administration, including omeprazole, probiotics, lactulose and so on. 1. Omeprazole: such as omeprazole enteric-coated tablets, omeprazole enteric-coated capsules, has the effect of inhibiting gastric acid, clinically and Trimethoprim can be used in the treatment of gastric ulcer, duodenal ulcer and other diseases. 2. Probiotics: such as bifidobacteria, lactobacilli, etc., have the effect of regulating the intestinal tract, combined with Trimebutine treatment can effectively improve the intestinal flora disorders caused by diarrhea. 3. Lactulose: has the effect of promoting intestinal peristalsis, and can effectively relieve constipation. If combined with Trimethoprim treatment, it can improve the constipation caused by intestinal disorders. It is prohibited if you are allergic to any of the components of Trimethoprim, and if you suffer from some chronic diseases, such as high blood pressure, coronary heart disease, and so on. There may be nausea, vomiting, stomach bloating and other symptoms during the use of the drug, which can be relieved after stopping the drug. The use of drugs should be carried out under the guidance of a doctor, the occurrence of adverse drug reactions to seek medical attention in time to avoid the development of the disease.