Syphilis rash symptoms are skin and mucous membrane damage, with diverse types of lesions, including macular rash, maculopapular rash, papular rash, scaly lesions, follicular rash, and pustular rash, etc. They are distributed on the trunk and limbs, etc., and are often generalized and symmetrical. Syphilis rash refers to the second stage of syphilis, the syphilis spirochete enters the blood circulation through the lymph nodes, resulting in systemic symptoms, and the rash appears in a systemic range. A systemic syphilis rash can be a generalized macular rash, papular rash, or in some cases, pustular rash. The maculopapular rash is the earliest skin lesion that occurs in stage 2 syphilis, and is light red, round or oval, and well defined. Dark erythema and desquamative maculopapular rash on the palms and metatarsals, eczema or flat warts on the vulva and perianal area are the characteristic damages. The rash is usually not itchy. Symptoms of syphilis rash is the content of the above, the danger of the disease can not be ignored, it is recommended to do a good job of related preventive work, such as symptoms of timely medical treatment, usually pay attention to personal hygiene, the onset of the disease and to avoid sexual intercourse during the treatment.