The treatment of odontogenic sinusitis is the complete elimination of the source of infection, which can be treated with medication and surgery. Odontogenic sinusitis is an inflammation of the maxillary sinuses caused by dental-related factors. Triggers include infection of maxillary teeth, trauma, maxillary surgery or dental surgery, the lesion is mostly unilateral, clinical symptoms are common ipsilateral upper teeth pain, headache, nasal congestion, runny nose, nasal odor, and even facial swelling and fever. Drug treatment: commonly used broad-spectrum antibiotics plus anti-anaerobic drugs, such as amoxicillin clavulanate potassium, cefuroxime, metronidazole, ornidazole and other drugs. The route of administration is determined according to the severity of the disease, and the drugs should be used in strict compliance with medical advice. Surgical treatment: This includes treatment of dental disease, such as tooth extraction and root canal therapy, as well as naso-endoscopic maxillary sinus surgery to remove lesions from the maxillary sinuses and expand drainage. For odontogenic maxillary sinusitis, it is recommended to consult a hospital and follow the doctor’s instructions for standardized treatment.