If the prostate PSA has been high for 10 years, prostate aspiration biopsy is recommended to further clarify the diagnosis. PSA is a tumor marker for prostate cancer, if the value has been high for 10 years, consider the possibility of prostate cancer. Of course, PSA can be affected by a variety of factors, such as prostate hyperplasia, prostatitis, anal diagnosis, catheterization and so on. However, if the PSA has been consistently elevated over a period of 10 years, the possibility of prostate cancer should be noted and a prostate aspiration biopsy is recommended. Prior to prostate puncture biopsy, a professional doctor should perform anal diagnosis of the prostate gland and conduct magnetic resonance examination of the prostate gland in order to clarify the location of the lesion and facilitate the guided operation. The puncture will be localized by ultrasound, and the punctured tissue will be sent to pathology. If it is prostate cancer, further treatment, such as surgical treatment or endocrine treatment, will be needed.