The causes of endocrine disorders include hormone resistance in target tissues, too little hormone production, and too much hormone production. 1. Hormone resistance in target tissues: this refers to the situation that the process of hormone production in the body is normal, but the hormone cannot work in the target organ due to some reasons, such as thyroid hormone resistance syndrome caused by mutation of the thyroid receptor gene and dwarfism caused by mutation of the growth hormone receptor gene. 2. Underproduction of hormones: This condition is caused by defective hormone synthesis in endocrine glands and destruction of endocrine glands, which is usually associated with autoimmune damage, infection, surgical resection, ischemic necrosis and other factors. 3. Excessive hormone production: Clinical causes of this condition include genetic abnormality, excessive intake of exogenous hormones, endocrine gland tumors, endocrine syndrome with tumors, and autoantibody production. If the above conditions exist, it is recommended to consult a doctor for a clear diagnosis and further targeted treatment.