The blisters on the feet are clinically known as friction blisters, which are caused by friction stimulation that makes the local tissue fluid oozing out to the tissue gap, and can be treated by replacing the shoes that fit the feet, draining, and using medicines and so on. 1. Replacement of suitable shoes and avoidance of long-distance traveling: Friction blisters on feet are mainly caused by wear and tear of feet due to ill-fitting shoes or long-distance traveling. Therefore, if you have abrasion blisters on your feet, you need to change comfortable shoes in time to reduce the local friction. 2. Drainage: If the blisters on the feet are large and the exudate is more, you need to go to the hospital to pick the bottom end of the blisters to drain out the liquid, and use iodine povidone to disinfect the local skin in a timely manner. 3. the use of drugs: can be used under the guidance of the doctor erythromycin ointment, mupirocin ointment and other drugs for treatment, has a certain anti-inflammatory and antibacterial effect, conducive to the recovery of the skin, and can play a role in preventing infection. The blisters on the feet, need to actively listen to the professional doctor’s advice to deal with, to avoid improper treatment to aggravate the condition.