The presence of hairy white spots on the tongue in patients with HIV is usually oral hairy leukoplakia, which is generally considered to be a highly prognostic sign of AIDS. AIDS is a sexually transmitted disease, and patients can develop immunodeficiency as a result of HIV infection, making them susceptible to a combination of oral hairy leukoplakia. The cause of oral furuncle leukoplakia is not fully understood and may be related to the replication of the EBV virus in the keratinized epithelial cells of the tongue and buccal mucosa. Hairy white spots on the tongue caused by AIDS cannot be shaved off and treatment with antifungal drugs is ineffective; EBV can be detected by biopsy. If you have hairy white spots on the tongue, you must seek medical treatment in time to avoid delaying the condition and causing adverse consequences.