Adrenocortical adenoma is usually treated by surgery, including laparoscopic surgery, open surgery, etc. After surgery, hormone replacement therapy can be chosen according to individual conditions. Adrenal cortex can secrete glucocorticoid, saline corticosteroid, sex hormone, and according to the secreted hormones, clinical manifestations are mostly Cushing’s syndrome, primary aldosteronism and other diseases. Currently, surgical treatment is the mainstay, including laparoscopic surgery and open surgery, etc. After surgery, if the hormones return to normal, it will be basically cured, and if the hormones drop after surgery, replacement therapy will be needed. Adrenocortical adenoma should seek medical treatment in time, complete relevant examinations, follow the doctor’s instructions for treatment, and have regular postoperative review and follow-up.