Rapid plasma reactivity for syphilis (RPR) is a non-syphilis spirochete antigen test. Negative RPR means that you are not currently infected with syphilis (including never infected with syphilis and previously infected with syphilis but cured), but you need to combine it with a syphilis spirochete antigen test to determine the presence of syphilis. RPR is one of the non-syphilis spirochete antigen tests, along with VDRL, USR and TRUST, which measure serum anticardiolipin antibodies, which are non-specific antibodies. It is generally used as a screening and quantitative test to observe efficacy, relapse and reinfection, and is negative after cure. These non-specific antibodies can be detected by RPR at 4-10 weeks post-infection, noting that RPR can be false-positive, e.g., pregnancy and autoimmune diseases can be RPR-positive. Combined with the syphilis spirochete antigen serologic test to determine, both negative, basically can be ruled out syphilis; if the RPR negative, specific antibody positive, represents the previous early syphilis has been cured. Relevant test results should be interpreted under the guidance of a doctor, please consult a doctor promptly.