Urine test immunoglobulin G is high for most pathological reasons, mainly for impaired renal function, common diseases such as diabetic nephropathy, nephrotic syndrome, etc., for specific causes of antihypertensive, urinary protein and other treatments; in addition, we can not rule out physiological conditions such as strenuous activities, emotional stress, etc., at this time, no treatment, pay attention to rest, and regular review can be. Infection, toxins, immunity, metabolism and other factors lead to the destruction of the glomerular capillary barrier, filtration membrane pore size or impaired charge barrier effect, exceeding the tubular reabsorption capacity and the formation of proteinuria. Pathological factors are common in diabetic nephropathy, nephrotic syndrome, etc. At this time, the use of dagliflozin, prednisone acetate, valsartan, cyclophosphamide and other drugs prescribed by the doctor to lower glucose, lower urinary protein treatment; physiological factors, such as strenuous activities, emotional stress, late at night and so on may also lead to the rise of immunoglobulin G, then we need to pay attention to rest, regular review. The above medications should be used in accordance with the doctor’s instructions, and should not be used without authorization, so as not to aggravate the condition. Urine test immunoglobulin G is high for many reasons, the patient needs to go to the regular hospital for further examination, to clarify the specific causes of the disease, and cooperate with the doctor to actively treat.