Pain on one side of the head and no pain on the other side may be migraine, which can be clinically classified as primary and secondary. The exact cause of primary migraine is not clear, but may be related to genetic factors. It is a primary neurovascular headache, and patients mainly present with recurrent pulsating headache, most of them can present with unilateral distribution, often accompanied by nausea and vomiting, and a few patients can have aura of visual, sensory and motor disorders before the attack. Treatment of the disease is mainly symptomatic, with oral acetaminophen, ibuprofen and indomethacin for mild cases, and ergotamine caffeine, zolmitriptan and sumatriptan for moderate and severe cases. Patients with secondary migraine with a clear etiology, common causes include cranial tumors and patients with trigeminal neuralgia, temporal neuralgia, and greater occipital neuralgia, may also present with headaches on one side. In addition, it may also be seen in patients with paranasal sinusitis, such as maxillary sinusitis, mandibular sinusitis, and frontal sinusitis, who can all present with a headache on one side. In addition, patients with dental pain may also have a headache on one side.