Long-term consumption of painkillers may cause some harm to the human body, the specific harm has the following aspects: First, the digestive system will have a certain impact, often lead to gastrointestinal dysfunction and gastrointestinal adverse reactions, and even the emergence of related gastritis, gastric ulcers and other chronic gastrointestinal diseases. Secondly, it has certain effect on kidney, which may lead to necrosis of renal papilla, even renal insufficiency, uremia, etc. It is found that long-term consumption of painkillers may also induce kidney cancer and bladder cancer, especially the harm of long-term consumption of painkillers by elderly patients is more serious. Third, the effect on blood is very serious, often cause white blood cells and neutrophils decrease. Fourth, the effect on liver is more serious, which may lead to abnormal liver function, elevated liver enzymes and so on.