After interferon injection for hepatitis B, flu-like symptoms can generally appear, manifesting as fever, chills, headache, muscle aches and peripheral weakness, as well as transient peripheral thrombocytopenia and decreased white blood cells, which need to be discontinued if there is a significant decrease in white blood cells and platelets. In addition, psychiatric abnormalities can occur, manifesting as depression, delusions, severe anxiety and other symptoms of mental illness, which also require timely discontinuation of interferon when symptoms are severe. The autoimmune disease can occur after interferon injection, which can lead to autoantibodies, hypo- or hyperthyroidism, rheumatoid arthritis, systemic lupus erythematosus and other diseases. Other rare side effects include kidney damage, cardiovascular complications, retinal complications, hearing loss, interstitial pneumonia, etc. You need to strictly grasp the indications and contraindications before injecting interferon, and if there are certain contraindications, you cannot inject interferon.