Patients with otitis media who do not take timely and effective treatment measures may experience a gradual aggravation of the acute inflammatory condition of the middle ear, including systemic symptoms and purulent infection. Systemic symptoms: The degree of pain in the patient’s ear may gradually worsen, even causing systemic symptoms such as chills and fever. 2. Purulent infection: Purulent infection may also occur in the middle ear cavity, which may lead to secondary eardrum perforation. The purulent secretions in the middle ear cavity will flow out into the ear canal through the eardrum perforation, causing the patient to have symptoms of pus flowing from the ear. If active and effective anti-infective treatment is not taken, the inflammatory condition of the middle ear may persist, resulting in a long-term, persistent tympanic membrane perforation, leading to chronic suppurative otitis media, and may also cause damage to the structure of the middle ear cavity auditory chain, resulting in inner ear disease.