The appearance of full moon face is related to the body’s glucocorticoid excess, may be of medical origin, but also may be adrenal hyperplasia or adrenal tumors due to Cushing’s syndrome. Nephrotic syndrome, as well as connective tissue diseases, need to take long-term treatment with glucocorticoid drugs such as prednisone, which can lead to excess glucocorticoids of medical origin to appear full-moon face, excluding the side effects of the drug, considering that it is adrenal hyperplasia or adrenal tumors, which can lead to an increase in their own production and secretion of glucocorticoids. Excessive glucocorticoid can affect the metabolism of fat and sugar, leading to fat accumulation in the face and trunk to induce full moon face and buffalo back. To rule out the medical origin of full moon face, adrenal function test and adrenal ultrasound should be done, and serious adrenal hyperplasia or adrenal tumor should be treated with timely surgery.